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1

Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes

Watson, Dionysios C., Yung, Bryant C., Bergamaschi, Cristina, Chowdhury, Bhabadeb, Bear, Jenifer, Stellas, Dimitris, Morales-Kastresana, Aizea, Jones, Jennifer C., Felber, Barbara K., Chen, Xiaoyuan,

Journal:

Journal of Extracellular Vesicles

Year:

2018

Language:

english

File:

PDF, 3.56 MB

english, 2018

2

Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo

Natalia Suarez, Carlos Alfaro, Juan Dubrot, Asis Palazon, Elixabet Bolaños, Lorena Erro, Sandra Hervas-Stubbs, Ivan Martinez-Forero, Aizea Morales-Kastresana, Salvador Martin-Algarra, Bruno Sangro, Fe

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 1.69 MB

english, 2011

3

Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ

Juan Dubrot, Francisca Milheiro, Carlos Alfaro, Asis Palazón, Ivan Martinez-Forero, Jose L. Perez-Gracia, Aizea Morales-Kastresana, José L. Romero-Trevejo, María C. Ochoa, Sandra Hervás-Stubbs, Jesús

Journal:

Cancer Immunology, Immunotherapy

Year:

2010

Language:

english

File:

PDF, 888 KB

english, 2010

4

PS2-082 Immunological effects of gene transfer with the sushi domain of IL-15Rα and a chimeric protein consisting of IL-15 fused to apolipoprotein A-1

M.C. Ochoa, J. Fioravanti, E.H. Duitman, J. Medina-Echeverz, A. Palazon, A. Arina, J. Dubrot, C. Alfaro, A. Morales-Kastresana, O. Murillo, S. Hervas-Stubbs, J. Prieto, P. Berraondo, I. Melero

Journal:

Year:

2011

Language:

english

File:

PDF, 46 KB

english, 2011

5

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

Palazon, A., Aragones, J., Morales-Kastresana, A., de Landazuri, M. O., Melero, I.

Journal:

Clinical Cancer Research

Year:

2012

Language:

english

File:

PDF, 2.99 MB

english, 2012

6

The HIF-1 Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

Palazon, A., Martinez-Forero, I., Teijeira, A., Morales-Kastresana, A., Alfaro, C., Sanmamed, M. F., Perez-Gracia, J. L., Penuelas, I., Hervas-Stubbs, S., Rouzaut, A., Landazuri, M. O. d., Jure-Kunkel

Journal:

Cancer Discovery

Year:

2012

Language:

english

File:

PDF, 12.66 MB

english, 2012

7

Agonist Antibodies to TNFR Molecules That Costimulate T and NK Cells

Melero, I., Hirschhorn-Cymerman, D., Morales-Kastresana, A., Sanmamed, M. F., Wolchok, J. D.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 892 KB

english, 2013

8

Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb

Aizea Morales-Kastresana, Elena Catalán…

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2013

Language:

english

File:

PDF, 322 KB

english, 2013

9

Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

Palazon, A., Teijeira, A., Martinez-Forero, I., Hervas-Stubbs, S., Roncal, C., Penuelas, I., Dubrot, J., Morales-Kastresana, A., Perez-Gracia, J. L., Ochoa, M. C., Ochoa-Callejero, L., Martinez, A., L

Journal:

Cancer Research

Year:

2011

Language:

english

File:

PDF, 1.29 MB

english, 2011

10

Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carcinoma

Aizea Morales-Kastresana,Sanmamed F Miguel…

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2013

Language:

english

File:

PDF, 63 KB

english, 2013

11

Combined Immunostimulatory Monoclonal Antibodies Extend Survival in an Aggressive Transgenic Hepatocellular Carcinoma Mouse Model

Morales-Kastresana, A., Sanmamed, M. F., Rodriguez, I., Palazon, A., Martinez-Forero, I., Labiano, S., Hervas-Stubbs, S., Sangro, B., Ochoa, C., Rouzaut, A., Azpilikueta, A., Bolanos, E., Jure-Kunkel,

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 1.79 MB

english, 2013

12

Better Performance of CARs Deprived of the PD-1 Brake

Morales-Kastresana, A., Labiano, S., Quetglas, J. I., Melero, I.

Journal:

Clinical Cancer Research

Year:

2013

Language:

english

File:

PDF, 398 KB

english, 2013

13

T Cell Costimulation with Anti-CD137 Monoclonal Antibodies Is Mediated by K63-Polyubiquitin-Dependent Signals from Endosomes

Martinez-Forero, I., Azpilikueta, A., Bolanos-Mateo, E., Nistal-Villan, E., Palazon, A., Teijeira, A., Perez-Chacon, G., Morales-Kastresana, A., Murillo, O., Jure-Kunkel, M., Zapata, J. M., Melero, I.

Journal:

The Journal of Immunology

Year:

2013

Language:

english

File:

PDF, 1.68 MB

english, 2013

14

Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb

Weigelin, Bettina, Bolaños, Elixabet, Teijeira, Alvaro, Martinez-Forero, Ivan, Labiano, Sara, Azpilikueta, Arantza, Morales-Kastresana, Aizea, Quetglas, José I., Wagena, Esther, Sánchez-Paulete, Alfon

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 1.45 MB

english, 2015

15

CD8 T Cell Priming in the Presence of IFN- Renders CTLs with Improved Responsiveness to Homeostatic Cytokines and Recall Antigens: Important Traits for Adoptive T Cell Therapy

Hervas-Stubbs, S., Mancheno, U., Riezu-Boj, J.-I., Larraga, A., Ochoa, M. C., Alignani, D., Alfaro, C., Morales-Kastresana, A., Gonzalez, I., Larrea, E., Pircher, H., Le Bon, A., Lopez-Picazo, J. M.,

Journal:

The Journal of Immunology

Year:

2012

Language:

english

File:

PDF, 1.46 MB

english, 2012

16

Combinations of immunostimulatory antibodies with synergistic effects against spontaneous cancer

Morales-Kastresana, Aizea, Labiano, Sara, Gütgemann, Ines, Melero, Ignacio

Journal:

Year:

2014

Language:

english

File:

PDF, 200 KB

english, 2014

17

Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2R null immunodeficient mice

Fernandez de Sanmamamed, M., Lopez Rodriguez, I., Schalper, K. A., Onate, C., Azpilikueta, A., Rodriguez-Ruiz, M. E., Morales-Kastresana, A., Labiano, S., Perez-Gracia, J. L., Martin-Algarra, S., Alfa

Journal:

Cancer Research

Year:

2015

Language:

english

File:

PDF, 1.42 MB

english, 2015

18

The liver, liver metastasis and liver cancer: a special case for immunotherapy with cytokines and immunostimulatory monoclonal antibodies

Mazzolini, Guillermo, Ochoa, María C, Morales-Kastresana, Aizea, Sanmamed, Miguel F, Melero, Ignacio

Journal:

Year:

2012

Language:

english

File:

PDF, 530 KB

english, 2012

19

Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells

Sanchez-Paulete, A. R., Cueto, F. J., Martinez-Lopez, M., Labiano, S., Morales-Kastresana, A., Rodriguez-Ruiz, M. E., Jure-Kunkel, M., Azpilikueta, A., Aznar, M. A., Quetglas, J. I., Sancho, D., Meler

Journal:

Cancer Discovery

Year:

2015

Language:

english

File:

PDF, 3.29 MB

english, 2015

20

Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression

Unzu, C, Melero, I, Hervás-Stubbs, S, Sampedro, A, Mancheño, U, Morales-Kastresana, A, Serrano-Mendioroz, I, de Salamanca, R E, Benito, A, Fontanellas, A

Journal:

Year:

2015

Language:

english

File:

PDF, 1.06 MB

english, 2015

21

Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism

Labiano, Sara, Palazón, Asis, Bolaños, Elixabet, Azpilikueta, Arantza, R. Sánchez-Paulete, Alfonso, Morales-Kastresana, Aizea, Quetglas, Jose I., Perez-Gracia, José L., Gúrpide, Alfonso, Rodriguez-Rui

Journal:

Year:

2016

Language:

english

File:

PDF, 1.18 MB

english, 2016

22

Efficient production and enhanced tumor delivery of engineered extracellular vesicles

Watson, Dionysios C., Bayik, Defne, Srivatsan, Avinash, Bergamaschi, Cristina, Valentin, Antonio, Niu, Gang, Bear, Jenifer, Monninger, Mitchell, Sun, Mei, Morales-Kastresana, Aizea, Jones, Jennifer C.

Journal:

Year:

2016

Language:

english

File:

PDF, 5.38 MB

english, 2016

23

NanoFACS: Extracellular Vesicle Subset Sorting for Personalized Medicine and Biodosimetry

Jones, J.C., Morales-Kastresana, A., Kesarwala, A.H., Jenkins, L., Choyke, P., Camphausen, K.A., Berzofsky, J.

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2016

Language:

english

File:

PDF, 73 KB

english, 2016

24

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry

Morales-Kastresana, Aizea, Telford, Bill, Musich, Thomas A., McKinnon, Katherine, Clayborne, Cassandra, Braig, Zach, Rosner, Ari, Demberg, Thorsten, Watson, Dionysios C., Karpova, Tatiana S., Freeman,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.78 MB

english, 2017

25

NanoFACS and Flow Cytometric Molecular Profiling of Circulating Extracellular Vesicles

Jones, J.C., Morales-Kastresana, A., Savage, J., Rosner, A., Arscott, W.T., Barfield, A., Maecker, H., Knox, S.J., Camphausen, K.A., Berzofsky, J.A.

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2017

Language:

english

File:

PDF, 95 KB

english, 2017

26

Intratumorally delivered formulation, INT230-6, containing potent anticancer agents induces protective T cell immunity and memory

Bloom, Anja C., Bender, Lewis H., Tiwary, Shweta, Pasquet, Lise, Clark, Katharine, Jiang, Tianbo, Xia, Zheng, Morales-Kastresana, Aizea, Jones, Jennifer C., Walters, Ian, Terabe, Masaki, Berzofsky, Ja

Journal:

Year:

2019

Language:

english

File:

PDF, 5.27 MB

english, 2019